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Generated: July 21, 2019

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Patent: 9,629,924

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Summary for Patent: 9,629,924
Title:Conjugates of CC-1065 analogs and bifunctional linkers
Abstract: This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
Inventor(s): Beusker; Patrick Henry (Nijmegen, NL), Coumans; Rudy Gerardus Elisabeth (Nijmegen, NL), Elgersma; Ronald Christiaan (Nijmegen, NL), Menge; Wiro Michael Petrus Bernardus (Nijmegen, NL), Joosten; Johannes Albertus Frederikus (Nijmegen, NL), Spijker; Henri Johannes (Nijmegen, NL), De Groot; Franciscus Marinus Hendrikus (Nijmegen, NL)
Assignee: Syntarga BV (Nijmegen, NL)
Application Number:13/642,847
Patent Claims:see list of patent claims

Details for Patent 9,629,924

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up Syntarga BV (Nijmegen, NL) ➤ Sign Up RX Orphan search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,629,924

Country Patent Number Publication Date
South Africa 201208282 Jan 29, 2014
World Intellectual Property Organization (WIPO) 2011133039 Apr 12, 2012
World Intellectual Property Organization (WIPO) 2011133039 Oct 27, 2011
United States of America 2013224227 Aug 29, 2013
United States of America 2017274090 Sep 28, 2017
United States of America 2017333567 Nov 23, 2017
Country Patent Number Publication Date

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