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Last Updated: December 5, 2021

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Patent: 9,580,685

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Summary for Patent: 9,580,685
Title:Truncated epiderimal growth factor receptor (EGFRt) for transduced T cell selection
Abstract: A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein. For example, a gene encoding a truncated human epidermal growth factor receptor polypeptide (EGFRt) that lacks the membrane distal EGF-binding domain and the cytoplasmic signaling tail, but retains an extracellular epitope recognized by an anti-EGFR antibody is provided. Cells may be genetically modified to express EGFRt and then purified without the immunoactivity that would accompany the use of full-length EGFR immunoactivity. Through flow cytometric analysis, EGFRt was successfully utilized as an in vivo tracking marker for genetically modified human T cell engraftment in mice. Furthermore, EGFRt was demonstrated to have cellular depletion potential through cetuximab mediated antibody dependent cellular cytotoxicity (ADCC) pathways. Thus, EGFRt may be used as a non-immunogenic selection tool, tracking marker, a depletion tool or a suicide gene for genetically modified cells having therapeutic potential.
Inventor(s): Jensen; Michael (Bainbridge Island, WA)
Assignee: City of Hope (Duarte, CA)
Application Number:14/340,512
Patent Claims:see list of patent claims

Details for Patent 9,580,685

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2004-02-12 ⤷  Try it Free 2029-11-03
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2007-03-28 ⤷  Try it Free 2029-11-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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