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Last Updated: March 28, 2024

Patent: 9,574,010


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Summary for Patent: 9,574,010
Title:Stable heterodimeric antibody design with mutations in the Fc domain
Abstract: The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
Inventor(s): Spreter Von Kreudenstein; Thomas (Vancouver, CA), Dixit; Surjit Bhimarao (Richmond, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula Irene (Vancouver, CA), Poon; David Kai Yuen (Richmond, CA)
Assignee: Zymeworks Inc. (Vancouver, CA)
Application Number:13/668,098
Patent Claims:see list of patent claims

Details for Patent 9,574,010

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2031-11-04
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 02/19/2002 ⤷  Try a Trial 2031-11-04
Hoffmann-la Roche Inc. ZENAPAX daclizumab Injection 103749 12/10/1997 ⤷  Try a Trial 2031-11-04
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 05/12/1998 ⤷  Try a Trial 2031-11-04
Novartis Pharmaceuticals Corporation SIMULECT basiliximab For Injection 103764 01/02/2003 ⤷  Try a Trial 2031-11-04
Swedish Orphan Biovitrum Ab (publ) SYNAGIS palivizumab For Injection 103770 06/19/1998 ⤷  Try a Trial 2031-11-04
Swedish Orphan Biovitrum Ab (publ) SYNAGIS palivizumab Injection 103770 07/23/2004 ⤷  Try a Trial 2031-11-04
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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