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Last Updated: September 30, 2020

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Patent: 9,567,578

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Summary for Patent: 9,567,578
Title:Cell line containing a knockout of the glutamine synthetase (GS) gene and a method of producing target proteins using a GS knockout HEK293 cell line
Abstract: The present invention relates to a novel GS (glutamine synthetase) gene knock out transgenic HEK293 (human embryonic kidney 293) cell line and a production method of a target protein using the said transgenic HEK293 cell line. Particularly, the present inventors eliminated the expression of GS in the HEK293 cells in order to overcome a barrier of the cell line selection caused by the over-expression of GS, for producing a target protein by GS/MSX system, by which the efficiency of the cell line selection for the high production of a target protein would be increased and accordingly the protein production by the selected cell line would be increased, suggesting that the human originated transgenic HEK293 cell line could be efficiently used for the production of a target protein.
Inventor(s): Lee; Gyun-Min (Daejeon, KR), Yu; Da Young (Daejeon, KR), Noh; Soo Min (Daejeon, KR)
Assignee: Korea Advanced Institute of Science and Technology (Daejeon, KR)
Application Number:15/138,165
Patent Claims:see list of patent claims

Details for Patent 9,567,578

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Korea Advanced Institute of Science and Technology (Daejeon, KR) 2036-01-04 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Korea Advanced Institute of Science and Technology (Daejeon, KR) 2036-01-04 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Korea Advanced Institute of Science and Technology (Daejeon, KR) 2036-01-04 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Korea Advanced Institute of Science and Technology (Daejeon, KR) 2036-01-04 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

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McKinsey
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