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Generated: July 21, 2019

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Patent: 9,566,243

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Summary for Patent: 9,566,243

Title:	Apparatus and method for cryogranulating a pharmaceutical composition
Abstract:	Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.
Inventor(s):	Amoro; Edwin (West Haven, CT), Vanackere; Karel (Knokke-Heist, BE), White; Michael A. (Brookfield, CT)
Assignee:	MannKind Corporation (Valencia, CA)
Application Number:	14/065,609
Patent Claims:	see list of patent claims

Details for Patent 9,566,243

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	004	2015-01-23	➤ Sign Up	MannKind Corporation (Valencia, CA)	➤ Sign Up	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	003	2015-01-23	➤ Sign Up	MannKind Corporation (Valencia, CA)	➤ Sign Up	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	002	2015-01-23	➤ Sign Up	MannKind Corporation (Valencia, CA)	➤ Sign Up	RX	Orphan	search
Nps Pharms Inc	NATPARA	parathyroid hormone	INJECTABLE;INJECTION	125511	001	2015-01-23	➤ Sign Up	MannKind Corporation (Valencia, CA)	➤ Sign Up	RX	Orphan	search
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source

International Patent Family for US Patent 9,566,243

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Country	Patent Number	Publication Date
World Intellectual Property Organization (WIPO)	2011053959	May 05, 2011
United States of America	10052285	Aug 21, 2018
United States of America	2011100028	May 05, 2011
United States of America	2014044790	Feb 13, 2014
Country	Patent Number	Publication Date

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