Patent: 9,562,038
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Summary for Patent: 9,562,038
| Title: | Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus |
| Abstract: | The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI\'s, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI\'s bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. |
| Inventor(s): | Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) |
| Assignee: | YALE UNIVERSITY (New Haven, CT) |
| Application Number: | 13/988,251 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,562,038
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Eli Lilly And Company | HUMATROPE | somatropin | For Injection | 019640 | 06/23/1987 | ⤷ Try a Trial | 2030-11-18 |
| Eli Lilly And Company | HUMATROPE | somatropin | For Injection | 019640 | 10/16/1986 | ⤷ Try a Trial | 2030-11-18 |
| Eli Lilly And Company | HUMATROPE | somatropin | For Injection | 019640 | 02/04/1999 | ⤷ Try a Trial | 2030-11-18 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
