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Generated: September 19, 2017

Patent: ► Subscribe

Summary for Patent: ► Subscribe

Title:Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
Abstract: The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI\'s, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI\'s bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein.
Inventor(s): Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH)
Assignee: YALE UNIVERSITY (New Haven, CT)
Application Number:13/988,251
Patent Claim Types:
see list of patent claims
Compound; Composition; Dosage form;

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; SINGLE-USE1032340011989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; MULTIDOSE1032340021989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; MULTIDOSE1032340031989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; SINGLE-USE1032340041989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; SINGLE-USE1032340051989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; SINGLE-USE1032340061989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Amgen
EPOGEN/PROCRIT
epoetin alfa
VIAL; SINGLE-USE1032340071989-06-01► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Chiron
PROLEUKIN
aldesleukin
VIAL1032930011992-05-05► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
Interferon Sciences
ALFERON N INJECTION
interferon alfa-n3
VIAL1031580011989-10-10► Subscribe YALE UNIVERSITY (New Haven, CT) Spiegel; David (New Haven, CT), Parker; Christopher (Medina, OH) ► SubscribeRXsearch
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Summary for Patent: ► Subscribe

PCT Information
PCT FiledNovember 17, 2011PCT Application Number:PCT/US2011/061174
PCT Publication Date:May 24, 2012PCT Publication Number: WO2012/068366

International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
Australia2011329829Feb 09, 2017
Australia2011329829Jul 11, 2013
Brazil112013012309Aug 23, 2016
Canada2818308May 24, 2012
Chile2013001429Apr 11, 2014
China103402998Nov 20, 2013
China107011333Aug 04, 2017
Colombia6801635Nov 29, 2013
Eurasian Patent Organization201390726Jun 30, 2014
European Patent Office2640720May 28, 2014
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Daiichi Sankyo
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Moodys
Federal Trade Commission
Covington
Chubb
AstraZeneca

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