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Last Updated: March 26, 2023

Patent: 9,551,719

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Summary for Patent: 9,551,719
Title:BCL-2-like protein 11 SRM/MRM assay
Abstract: Specific peptides, and derived ionization characteristics of those peptides, from the Bcl-2-like protein 11 (BIM) are provided that are particularly advantageous for quantifying the BIM protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM). Such biological samples are chemically preserved and fixed where the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. A protein sample is prepared from the biological sample using the Liquid Tissue.TM. reagents and protocol, and the BIM protein is quantitated in the Liquid Tissue.TM. sample by the method of SRM/MRM mass spectrometry by quantitating in the protein sample at least one or more of the peptides described. These peptides can be quantitated if they reside in a modified or an unmodified form. An example of a modified form of a BIM peptide is phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence.
Inventor(s): Krizman; David (Gaithersburg, MD), Hembrough; Todd (Gaithersburg, MD), Thyparambil; Sheeno (Frederick, MD), Liao; Wei-Li (Herndon, VA)
Assignee: EXPRESSION PATHOLOGY, INC. (Rockville, MD)
Application Number:13/942,574
Patent Claims:see list of patent claims

Details for Patent 9,551,719

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 See Plans and Pricing 2031-01-13
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 See Plans and Pricing 2031-01-13
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 See Plans and Pricing 2031-01-13
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 See Plans and Pricing 2031-01-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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