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Last Updated: July 11, 2020

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Patent: 9,549,538

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Summary for Patent: 9,549,538
Title:Transgenic animal for production of antibodies having minimal CDRs
Abstract: A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.
Inventor(s): Harriman; William Don (Alameda, CA), Etches; Robert (Oakland, CA), Leighton; Philip A. (San Francisco, CA)
Assignee: CRYSTAL BIOSCIENCE, INC. (Emeryville, CA)
Application Number:15/188,724
Patent Claims:see list of patent claims

Details for Patent 9,549,538

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial CRYSTAL BIOSCIENCE, INC. (Emeryville, CA) 2029-08-13 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial CRYSTAL BIOSCIENCE, INC. (Emeryville, CA) 2029-08-13 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial CRYSTAL BIOSCIENCE, INC. (Emeryville, CA) 2029-08-13 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 9,549,538

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