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Generated: September 23, 2019

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Patent: 9,539,263

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Summary for Patent: 9,539,263

Title:	Subcutaneously administered anti-IL-6 receptor antibody for treatment of systemic sclerosis
Abstract:	The present application discloses methods for treating an IL-6-mediated disorder such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic JIA (sJIA), polyarticular course JIA (pcJIA), systemic sclerosis, or giant cell arteritis (GCA), with subcutaneously administered antibody that binds interleukin-6 receptor (anti-IL-6R antibody). In particular, it relates to identification of a fixed dose of anti-IL-6R antibody, e.g. tocilizumab, which is safe and effective for subcutaneous administration in patients with IL-6-mediated disorders. In addition, formulations and devices useful for subcutaneous administration of an anti-IL-6R antibody are disclosed.
Inventor(s):	Zhang; Xiaoping (Wayne, NJ), Terao; Kimio (Funabashi, JP), Jahreis; Angelika M. (Menlo Park, CA)
Assignee:	Genentech, Inc. (South San Francisco, CA) Hoffmann-La Roche, Inc. (Nutley, NJ) Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:	14/062,005
Patent Claims:	see list of patent claims

Details for Patent 9,539,263

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	ACTEMRA	tocilizumab	INJECTABLE; INJECTION	125276	001	2010-01-08	➤ Sign Up	Genentech, Inc. (South San Francisco, CA) Hoffmann-La Roche, Inc. (Nutley, NJ) Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)	2030-11-08	RX		search
Genentech	ACTEMRA	tocilizumab	INJECTABLE; INJECTION	125276	002	2010-01-08	➤ Sign Up	Genentech, Inc. (South San Francisco, CA) Hoffmann-La Roche, Inc. (Nutley, NJ) Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)	2030-11-08	RX		search
Genentech	ACTEMRA	tocilizumab	INJECTABLE; INJECTION	125276	003	2010-01-08	➤ Sign Up	Genentech, Inc. (South San Francisco, CA) Hoffmann-La Roche, Inc. (Nutley, NJ) Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)	2030-11-08	RX		search
Genentech	ACTEMRA	tocilizumab	INJECTABLE;INTRAVENOUS, SUBCUTANEOUS	125472	001	2013-10-21	➤ Sign Up	Genentech, Inc. (South San Francisco, CA) Hoffmann-La Roche, Inc. (Nutley, NJ) Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)	2030-11-08	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 9,539,263

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Country	Patent Number	Publication Date
Brazil	112013011305	Jul 25, 2017
Canada	2817216	May 18, 2012
China	103476793	Dec 25, 2013
China	104998254	Oct 28, 2015
European Patent Office	2638067	Sep 18, 2013
European Patent Office	2787007	Mar 11, 2015
>Country	>Patent Number	>Publication Date

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