Patent: 9,528,099
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Summary for Patent: 9,528,099
Title: | Fusion proteins of collagen-binding domain and parathyroid hormone |
Abstract: | Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented. |
Inventor(s): | Gensure; Robert C. (New York, NY), Sakon; Joshua (Fayetteville, AR), Matsushita; Osamu (Okayama, JP), Ponnapakkam; Tulasi (New York, NY) |
Assignee: | Ochsner Clinic Foundation (N/A) National University Corporation Kagawa University (JP) The Board of Trustees of the University of Arkansas (N/A) |
Application Number: | 14/743,629 |
Patent Claims: | see list of patent claims |
Details for Patent 9,528,099
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Smith & Nephew, Inc. | SANTYL | collagenase | Ointment | 101995 | 06/04/1965 | ⤷ Try a Trial | 2027-04-09 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |