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Generated: October 19, 2017

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Summary for Patent: ► Subscribe

Title:Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity
Abstract: The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to EGP-1 (TROP-2), CEACAM5, CEACAM6, CD74, CD19, CD20, CD22, CSAp, HLA-DR, AFP or MUC5ac and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 24 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy.
Inventor(s): Govindan; Serengulam V. (Summit, NJ), Goldenberg; David M. (Mendham, NJ)
Assignee: Immunomedics, Inc. (Morris Plains, NJ)
Application Number:14/674,117
Patent Claim Types:
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Use;

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Merck
ELSPAR
asparaginase
VIAL1010630011978-01-10► Subscribe Immunomedics, Inc. (Morris Plains, NJ) Govindan; Serengulam V. (Summit, NJ), Goldenberg; David M. (Mendham, NJ) ► SubscribeRXsearch
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