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Last Updated: September 22, 2020

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Patent: 9,522,876

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Summary for Patent: 9,522,876
Title:Cytotoxic and anti-mitotic compounds, and methods of using the same
Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. The compounds have the following structure (I): ##STR00001## including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having structure (I).
Inventor(s): Winters; Geoffrey C. (Vancouver, CA), Mandel; Alexander L. (Vancouver, CA), Hedberg; Bradley J. (Vancouver, CA), Babcook; John (Vancouver, CA), Rich; James R. (Vancouver, CA), Hsieh; Tom Han Hsiao (Vancouver, CA), Bourque; Elyse Marie Josee (Blaine, WA)
Assignee: ZYMEWORKS INC. (Vancouver, BC, unknown)
Application Number:14/213,504
Patent Claims:see list of patent claims

Details for Patent 9,522,876

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial ZYMEWORKS INC. (Vancouver, BC, unknown) 2033-03-15 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial ZYMEWORKS INC. (Vancouver, BC, unknown) 2033-03-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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