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Last Updated: September 26, 2020

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Patent: 9,494,601

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Summary for Patent: 9,494,601
Title:Atypical hemolytic uremic syndrome (AHUS) biomarker proteins
Abstract: The disclosure provides biomarker proteins, a change in the concentration or activity level of which are associated with atypical hemolytic uremic syndrome (aHUS) or clinically meaningful treatment of aHUS with a complement inhibitor. Also provided are compositions and methods for interrogating the concentration and/or activity of one or more of the biomarker proteins in a biological fluid. The compositions and methods are useful for, among other things, evaluating risk for developing aHUS, diagnosing aHUS, determining whether a subject is experiencing the first acute presentation of aHUS, monitoring progression or abatement of aHUS, and/or monitoring response to treatment with a complement inhibitor or optimizing such treatment.
Inventor(s): McKnight; Susan Faas (Old Lyme, CT), Cofiell; Roxanne (Glastonbury, CT), Kukreja; Anjli (Fairfield, CT), Bedard; Krystin A. (N/A), Yan; Yan (Cheshire, CT)
Assignee: Alexion Pharmaceuticals, Inc. (New Haven, CT)
Application Number:15/013,833
Patent Claims:see list of patent claims

Details for Patent 9,494,601

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Alexion Pharm SOLIRIS eculizumab INJECTABLE; IV (INFUSION) 125166 001 2007-03-16   Start Trial Alexion Pharmaceuticals, Inc. (New Haven, CT) 2033-08-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Express Scripts
Boehringer Ingelheim

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