Patent: 9,493,738
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Summary for Patent: 9,493,738
| Title: | Method for producing high yield attenuated Salmonella strains |
| Abstract: | This invention relates to a novel method for growing attenuated mutant Salmonella typhi strains lacking galactose epimerase activity and harboring a recombinant DNA molecule. The method comprises the step of culturing said Salmonella typhi strain without adding glucose to the medium during the fermentation with a starting glucose amount that is depleted before reaching the stationary phase. The invention further relates to attenuated mutant Salmonella typhi strains obtainable by said method and to an attenuated mutant Salmonella typhi strain harboring a recombinant DNA molecule encoding a VEGF receptor protein for use as a vaccine. |
| Inventor(s): | Lubenau; Heinz (Neustadt an der Weinstrasse, DE), Siede; Holger (Ronnenberg, DE), Janssen; Renate (Hannover, DE), Springer; Marco (Wendlingen, DE) |
| Assignee: | VAXIMM AG (Basel, CH) |
| Application Number: | 14/366,186 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,493,738
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Emergent Travel Health, Inc. | VIVOTIF | typhoid vaccine live oral ty21a | Capsule | 103123 | 12/15/1989 | ⤷ Try a Trial | 2031-12-22 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
