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Last Updated: November 27, 2021

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Patent: 9,486,531

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Summary for Patent: 9,486,531
Title:Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
Abstract: The invention provides a controlled release biodegradable polymer formulation adapted for administering bioactive agents such as therapeutic proteins to a patient through implantation of a bolus that forms a depot within the patient\'s body tissues. The formulation includes a dehydrated inclusion complex of the bioactive agent within a hydrogel, wherein the hydrogel can comprise a polymerized polyalkyleneglycolyl diacrylate, and, optionally, polyalkyleneglycolyl monoacrylates, including methacrylates. Alternatively, the hydrogel can comprise hyaluronic acid, chitosan, agarose, polyvinylacetate, polyvinylpyrrolide, or polyvinylalcohol nanoparticles. The bioactive agent can be a macromolecular material, such as a protein. A method of forming the inventive formulation is also provided, as well as a method for using the formulation in the treatment of a malcondition in a patient in need thereof.
Inventor(s): Dadey; Eric (Furlong, PA), Watkins; Andrew (Drew) (Fort Collins, CO)
Assignee: INDIVIOR UK LIMITED (Slough, GB)
Application Number:12/995,956
Patent Claims:see list of patent claims

Details for Patent 9,486,531

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company HUMULIN R U-100 insulin human Injection 018780 1982-10-28 ⤷  Try it Free 2028-06-03
Eli Lilly And Company HUMULIN R U-500 insulin human Injection 018780 2015-12-29 ⤷  Try it Free 2028-06-03
Eli Lilly And Company HUMULIN R U-100 insulin human Injection 018780 1998-08-06 ⤷  Try it Free 2028-06-03
Eli Lilly And Company HUMULIN R U-500 insulin human Injection 018780 1994-03-31 ⤷  Try it Free 2028-06-03
Eli Lilly And Company HUMULIN R U-100 insulin human Injection 018780 2018-05-25 ⤷  Try it Free 2028-06-03
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2004-02-12 ⤷  Try it Free 2028-06-03
Eli Lilly And Company ERBITUX cetuximab Injection 125084 2007-03-28 ⤷  Try it Free 2028-06-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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McKinsey

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