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Last Updated: September 30, 2020

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Patent: 9,474,759

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Summary for Patent: 9,474,759
Title:Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
Inventor(s): Chang; Kyeong-Ok (Manhattan, KS), Kim; Yunjeong (Manhattan, KS), Groutas; William C. (Wichita, KS), Hua; Duy (Manhattan, KS), Saif; Linda J. (Wooster, OH)
Assignee: Kansas State University Research Foundation (Manhattan, KS) The Ohio State University (Columbus, OH) Wichita State University (Wichita, KS)
Application Number:14/347,756
Patent Claims:see list of patent claims

Details for Patent 9,474,759

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Kansas State University Research Foundation (Manhattan, KS) The Ohio State University (Columbus, OH) Wichita State University (Wichita, KS) 2031-09-27 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Kansas State University Research Foundation (Manhattan, KS) The Ohio State University (Columbus, OH) Wichita State University (Wichita, KS) 2031-09-27 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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