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Last Updated: November 29, 2021

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Patent: 9,468,676

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Summary for Patent: 9,468,676
Title:Antagonists of IL-6 to prevent or treat thrombosis
Abstract: The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis or hypercoagulation in patients having, or at risk of developing, diseases associated with abnormal blood coagulation or fibrinolysis and/or patients which are at increased risk or are being treated by a regimen that renders the patient at increased susceptibility to hypercoagulation or thrombosis such as patients who have previously had a stroke or heart attack or persons on a treatment regimen with a drug or chemotherapy and/or radiation that is associated with increased risk of thrombosis or hypercoagulation. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.
Inventor(s): Smith; Jeffrey T. L. (Bellevue, WA)
Assignee: ALDERBIO HOLDINGS LLC (Las Vegas, NV)
Application Number:13/511,390
Patent Claims:see list of patent claims

Details for Patent 9,468,676

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch Health Us, Llc IPRIVASK desirudin For Injection 021271 2003-04-04 ⤷  Try it Free 2029-11-24
Janssen Biotech, Inc. REOPRO abciximab Injection 103575 1994-12-22 ⤷  Try it Free 2029-11-24
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Moodys
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Harvard Business School
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AstraZeneca

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