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Last Updated: April 23, 2024

Patent: 9,465,027

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Summary for Patent: 9,465,027

Title:	Assays for detecting neutralizing autoantibodies to biologic therapy
Abstract:	The present invention provides assays for detecting and measuring the presence or level of neutralizing and non-neutralizing autoantibodies to biologics such as anti-TNF.alpha. drug therapeutics in a sample. The present invention is useful for monitoring the formation of neutralizing and/or non-neutralizing anti-drug antibodies over time while a subject is on biologic therapy. The present invention is also useful for predicting and/or determining the cross-reactivity of neutralizing anti-drug antibodies in a subject\'s sample with alternative biologic therapies. As such, the present invention provides information for guiding treatment decisions for those subjects receiving therapy with a biologic agent and improves the accuracy of optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment to biologic therapy.
Inventor(s):	Hauenstein; Scott (San Diego, CA), Ohrmund; Linda (San Diego, CA), Singh; Sharat (Rancho Santa Fe, CA), Wang; Shui Long (San Diego, CA)
Assignee:	Nestec S.A. (Vevey, CH)
Application Number:	14/144,261
Patent Claims:	see list of patent claims

Details for Patent 9,465,027

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	08/24/1998	⤷ Try a Trial	2031-07-06
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2031-07-06
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2031-07-06
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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