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Last Updated: September 23, 2020

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Patent: 9,459,263

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Summary for Patent: 9,459,263
Title:VEGF-A.sub.121 assay
Abstract: The invention provides a method for enriching the level of VEGF-A.sub.121 isoform in a sample by selectively removing the VEGF-A.sub.165 isoform from the sample using a neuropilin-1 pull-down procedure, then determining the total amount of VEGF-A remaining afterward. The invention provides methods of treating a patient suffering from a disease which may benefit from the administration of a VEGF antagonist by determining the level or ratio of VEGF-A.sub.121 in the patient\'s circulation. Methods of diagnosis, prognosis, monitoring, and patient stratification are also provided.
Inventor(s): Papadopoulos; Nicholas (LaGrangeville, NY), Dore; Anthony (Tarrytown, NY), MacDonald; Douglas (New York, NY)
Assignee: Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:14/811,056
Patent Claims:see list of patent claims

Details for Patent 9,459,263

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) 2033-05-22 RX Orphan search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 002 2004-02-26   Start Trial Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) 2033-05-22 RX Orphan search
Genentech LUCENTIS ranibizumab INJECTABLE; INJECTION 125156 001 2006-06-30   Start Trial Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) 2033-05-22 RX search
Regeneron Pharmaceuticals EYLEA aflibercept INJECTABLE; INJECTION 125387 001 2011-11-18   Start Trial Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) 2033-05-22 RX search
Eli Lilly And Co CYRAMZA ramucirumab INJECTABLE;INJECTION 125477 001 2014-04-21   Start Trial Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) 2033-05-22 RX search
Eli Lilly And Co CYRAMZA ramucirumab INJECTABLE;INJECTION 125477 002 2014-04-21   Start Trial Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) 2033-05-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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