Abstract: | Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, ##STR00001## as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. |
Inventor(s): | Trzupek; John David (Medford, MA), Lee; Katherine Lin (West Newton, MA), Bunnage; Mark Edward (Concord, MA), Han; Seungil (Mystic, CT), Hepworth; David (Concord, MA), Lovering; Frank Eldridge (Acton, MA), Mathias; John Paul (Concord, MA), Papaioannou; Nikolaos (Boston, MA), Strohbach; Joseph Walter (Wentzville, MO), Wright; Stephen Wayne (Old Lyme, CT), Zapf; Christoph Wolfgang (Marlborough, MA), Gavrin; Lori Krim (Villanova, PA), Lee; Arthur (Gaithersburg, MD), Curran; Kevin Joseph (Somerset, NJ), Dehnhardt; Christoph Martin (Burnaby, CA), Saiah; Eddine (Brookline, MA), Goldberg; Joel Adam (New Orleans, LA), Wang; Xiaolun (San Diego, CA), Vargas; Richard (Bedford, MA), Lowe; Michael Dennis (White Plains, NY), Patny; Akshay (Waltham, MA) |