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Last Updated: September 24, 2020

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Patent: 9,447,108

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Summary for Patent: 9,447,108
Title:Deuterated morphine derivatives
Abstract: The invention relates to new morphine derivatives deuterated at the 7,8-position of the morphine ring, furthermore to a process for the preparation thereof, and to pharmaceutical compositions comprising them. The new deuterated morphine derivatives show high and selective .mu.-opioid receptor binding activity leading to the benefit of higher analgesic activity at lower dosages inducing thereby reduced adverse effects compared to the hydrogenated derivatives. The compounds of the invention are useful for example in the treatment of pain or can be used as antitussive agents with a reduced risk of the possibility of drug abuse.
Inventor(s): Fulop; Ferenc (Szeged, HU), Mandity; Istvan (Szeged, HU)
Assignee: Szegedi Tudomanyegyetem (Szeged, HU)
Application Number:14/781,116
Patent Claims:see list of patent claims

Details for Patent 9,447,108

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial Szegedi Tudomanyegyetem (Szeged, HU) 2033-04-15 RX Orphan search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial Szegedi Tudomanyegyetem (Szeged, HU) 2033-04-15 RX Orphan search
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial Szegedi Tudomanyegyetem (Szeged, HU) 2033-04-15 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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