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Generated: July 23, 2019

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Patent: 9,427,480

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Summary for Patent: 9,427,480
Title:Duocarmycin ADCs for use in treatment of endometrial cancer
Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors expressing HER2, wherein the human solid tumor expressing HER2 is endometrial cancer, in particular uterine serous carcinoma (USC). In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of endometrial cancer, notably USC, with HER2 IHC 2- or 1+ and HER2 FISH negative tumor tissue status.
Inventor(s): Santin; Alessandro Davide (New Haven, CT), Goedings; Peter Johannes (Nijmegen, NL)
Assignee: Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT)
Application Number:14/859,221
Patent Claims:see list of patent claims

Details for Patent 9,427,480

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08 ➤ Sign Up Synthon Biopharmaceuticals B.V. (Nijmegen, NL) Yale University (New Haven, CT) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,427,480

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2015104373 Jul 16, 2015
World Intellectual Property Organization (WIPO) 2015104373 Sep 03, 2015
World Intellectual Property Organization (WIPO) 2015104385 Aug 27, 2015
World Intellectual Property Organization (WIPO) 2015104385 Jul 16, 2015
United States of America 10092659 Oct 09, 2018
Country Patent Number Publication Date

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