Get our Free Patent Expiration Newsletter

Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Chubb
Johnson and Johnson
Baxter
Farmers Insurance
Fish and Richardson

Generated: July 17, 2019

DrugPatentWatch Database Preview

Patent: 9,421,278

Try a free trialSee Plans and Pricing

« Back to Dashboard

Summary for Patent: 9,421,278
Title:Duocarmycin ADCS showing improved in vivo antitumor activity
Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumors with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).
Inventor(s): Dokter; Willem (Nijmegen, NL), Goedings; Peter Johannes (Nijmegen, NL), Verheijden; Gijsbertus Franciscus Maria (Nijmegen, NL), Beusker; Patrick Henry (Nijmegen, NL)
Assignee: Synthon Biopharmaceuticals B.V. (Nijmegen, NL)
Application Number:14/859,201
Patent Claims:see list of patent claims

Details for Patent 9,421,278

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08 ➤ Sign Up Synthon Biopharmaceuticals B.V. (Nijmegen, NL) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

Subscribe to access the full database, or try a Free Trial

International Patent Family for US Patent 9,421,278

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2015104373 Jul 16, 2015
World Intellectual Property Organization (WIPO) 2015104373 Sep 03, 2015
World Intellectual Property Organization (WIPO) 2015104385 Aug 27, 2015
World Intellectual Property Organization (WIPO) 2015104385 Jul 16, 2015
United States of America 10092659 Oct 09, 2018
United States of America 2016008486 Jan 14, 2016
Country Patent Number Publication Date

Subscribe to access the full database, or try a Free Trial

Make Better Decisions: Try a trial or see plans & pricing

Serving hundreds of leading biopharmaceutical companies globally:

US Army
Chinese Patent Office
McKesson
Baxter
Boehringer Ingelheim
Chubb

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.