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Last Updated: January 20, 2020

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Patent: 9,421,278

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Summary for Patent: 9,421,278
Title:Duocarmycin ADCS showing improved in vivo antitumor activity
Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumors with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).
Inventor(s): Dokter; Willem (Nijmegen, NL), Goedings; Peter Johannes (Nijmegen, NL), Verheijden; Gijsbertus Franciscus Maria (Nijmegen, NL), Beusker; Patrick Henry (Nijmegen, NL)
Assignee: Synthon Biopharmaceuticals B.V. (Nijmegen, NL)
Application Number:14/859,201
Patent Claims:see list of patent claims

Details for Patent 9,421,278

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Start Trial Synthon Biopharmaceuticals B.V. (Nijmegen, NL) 2034-01-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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