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Last Updated: December 5, 2019

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Patent: 9,404,087

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Summary for Patent: 9,404,087
Title:Insulin producing cells derived from pluripotent stem cells
Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
Inventor(s): Revel; Michel (Rehovot, IL), Chebath; Judith (Rehovot, IL), Slutsky; Guy (Holon, IL), Levy; Alon (Ramat-HaSharon, IL), Izrael; Michal (Rehovot, IL), Hasson; Arik (Kiryat-Ono, IL), Molakandov; Kfir (Yahud, IL), Kaufman; Rosalia (Rehovot, IL)
Assignee: Kadimastem Ltd. (Nes-Ziona, IL)
Application Number:13/989,805
Patent Claims:see list of patent claims

Details for Patent 9,404,087

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Kadimastem Ltd. (Nes-Ziona, IL) 2030-12-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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