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Last Updated: December 5, 2019

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Patent: 9,353,366

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Summary for Patent: 9,353,366
Title:Asparaginase and treating diseases associated with asparagine dependence
Abstract: Disclosed herein are polypeptides which exhibit asparaginase activity and little to no glutaminase activity. The polypeptides have sequences which correspond to W. succinogenes asparaginase, but have an amino acid residue other than proline at amino acid position 121. The polypeptides exhibit higher kinetic rates of asparaginase activity to glutaminase activity as compared to W. succinogenes asparaginase and Elspar.RTM., an E. coli asparaginase.
Inventor(s): Durden; Donald L. (La Jolla, CA)
Assignee: Children\'s Hospital Los Angeles (Los Angeles, CA)
Application Number:14/706,132
Patent Claims:see list of patent claims

Details for Patent 9,353,366

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Children\'s Hospital Los Angeles (Los Angeles, CA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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