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Last Updated: September 26, 2020

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Patent: 9,327,023

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Summary for Patent: 9,327,023
Title:HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
Abstract: The present invention relates to compositions, methods, and kits for treating cancers with HER2 targeting agents and preventing resistance thereto. In particular embodiments, non-HER2-amplified cancers are treated with HER2 targeting agents, wherein the cancer stem cells in the cancer express HER2 and/or HER2 indicator marker. The present invention also relates to compositions, methods, and kits for detecting expression of HER2 and/or a HER2 indicator marker in non-HER2-amplified cancer samples from a subject, and identifying the subject as responsive to treatment with a HER2 targeting agent and/or treating the subject with a HER2 targeting agent.
Inventor(s): Wicha; Max S. (Ann Arbor, MI), Korkaya; Hasan (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Application Number:13/660,333
Patent Claims:see list of patent claims

Details for Patent 9,327,023

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial The Regents of the University of Michigan (Ann Arbor, MI) 2031-10-25 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial The Regents of the University of Michigan (Ann Arbor, MI) 2031-10-25 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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