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Generated: November 20, 2018

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Patent: 9,326,974

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Summary for Patent: 9,326,974
Title:Methods and related compositions for the treatment of cancer
Abstract: A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit proliferation of such cells and preferably in an amount sufficient to lead to cancer cell death. The method is particularly directed to refractory cancer, particularly hormone refractory prostate cancer. The agents identified cause increased intracellular granularity in the cancer cells, and also convert adherent cancer cells to non-adherent cancer cells, leading to cancer cell death. Using the present invention, cancer cells undergo increased intracellular granularity at relatively low agent concentrations, while also inhibiting cell proliferation. Increased concentrations lead to conversion of adherent cancer cells to non-adherent cancer cells, then to cell death. While the exact mechanism of cancer cell degradation and death is not completely understood, the treated cancer cells, including refractory prostate cancer cells, give indications of cell death through an autophagic mechanism. Pharmaceutical compositions related to the presently disclosed methods are also disclosed.
Inventor(s): Thompson; Todd A. (Albuquerque, NM), Mackenzie; Debra (Albuquerque, NM), Oprea; Tudor I. (Albuquerque, NM), Sklar; Larry A. (Albuquerque, NM), Edwards; Bruce S. (Albuquerque, NM), Haynes; Mark (Albuquerque, NM)
Assignee: STC.UNM (Albuquerque, NM)
Application Number:14/449,957
Patent Claim Types:
see list of patent claims
Use; Composition; Dosage form;

Details for Patent 9,326,974

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ➤ Sign Up STC.UNM (Albuquerque, NM) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up STC.UNM (Albuquerque, NM) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up STC.UNM (Albuquerque, NM) ➤ Sign Up RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up STC.UNM (Albuquerque, NM) ➤ Sign Up RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; SINGLE-USE 103234 001 1989-06-01 ➤ Sign Up STC.UNM (Albuquerque, NM) ➤ Sign Up RX search
Amgen EPOGEN/PROCRIT epoetin alfa VIAL; MULTIDOSE 103234 002 1989-06-01 ➤ Sign Up STC.UNM (Albuquerque, NM) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,326,974

Country Document Number Publication Date
United States of America 2011224141 Sep 15, 2011
United States of America 2014343347 Nov 20, 2014
United States of America 8835506 Sep 16, 2014
World Intellectual Property Organization (WIPO) 2009148623 Dec 10, 2009
World Intellectual Property Organization (WIPO) 2009148623 Mar 25, 2010
Country Document Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
Boehringer Ingelheim
Baxter
McKinsey
Mallinckrodt
Merck
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Deloitte
Dow

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