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Last Updated: July 12, 2020

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Patent: 9,322,034

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Summary for Patent: 9,322,034
Title:Compositions and methods for detecting and modulating cell death by a translation regulated gene expression system
Abstract: The technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the TR element, that is a first open reading frame (ORF) sequence and encodes a polypeptide or a fragment thereof and is co-translated with the TR element. The technology further relates to mammalian cells and a transgenic animal comprising such expression cassette. Further included are kits comprising the expression cassette, and methods for determining toxicity, and killing a target cell.
Inventor(s): Carlock; Leon (Bloomfield, MI), Cypher; Maria (Magnolia, TX)
Assignee: Wayne State University (Detroit, MI)
Application Number:12/672,989
Patent Claims:see list of patent claims

Details for Patent 9,322,034

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Wayne State University (Detroit, MI) 2027-08-10 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Wayne State University (Detroit, MI) 2027-08-10 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Wayne State University (Detroit, MI) 2027-08-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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