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Generated: September 23, 2019

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Patent: 9,310,379

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Summary for Patent: 9,310,379
Title:Methods of crystallizing antibodies
Abstract: This invention relates to crystals of whole antibodies and fragments thereof, and formulations and compositions comprising such crystals. More particularly, methods are provided for the crystallization of high concentrations of whole antibodies, and fragments thereof, in large batches, and for the preparation of stabilized whole antibody crystals for use alone, or in dry or slurry formulations or compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active whole antibody crystals. The present invention further relates to methods using whole antibody crystals, antibody fragment crystals, or compositions or formulations comprising such crystals for biomedical applications, including biological delivery to humans and animals. More particularly, whole antibody crystals or antibody fragment crystals, or crystal compositions or formulations thereof, are used as a carrier-free delivery system which can slowly release active whole antibodies or fragments thereof, to a subject, where and when they are needed.
Inventor(s): Shenoy; Bhami (Woburn, MA), Govardhan; Chandrika P. (Lexington, MA), Yang; Mark X. (Newton, MA), Margolin; Alexey L. (Newton, MA)
Assignee: Ajinomoto Althea, Inc. (San Diego, CA)
Application Number:12/237,917
Patent Claims:see list of patent claims

Details for Patent 9,310,379

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26 ➤ Sign Up Ajinomoto Althea, Inc. (San Diego, CA) 2020-12-28 RX search
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24 ➤ Sign Up Ajinomoto Althea, Inc. (San Diego, CA) 2020-12-28 RX Orphan search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25 ➤ Sign Up Ajinomoto Althea, Inc. (San Diego, CA) 2020-12-28 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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