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Last Updated: December 6, 2021

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Patent: 9,303,044

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Summary for Patent: 9,303,044
Title:7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders
Abstract: The present invention relates to compounds and compositions of Formula P useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of variables A, B, R.sub.2, R.sub.3, R.sub.4, R.sub.a, R.sub.a\', R.sub.b, R.sub.b\', R.sub.c, R.sub.d, R.sub.d\', R.sub.e, and R.sub.e\' are provided in the disclosure. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
Inventor(s): Coller; Barry S. (New York, NY), Thomas; Craig (Rockville, MD), Filizola; Marta (New York, NY), McCoy; Joshua (Portland, ME), Huang; Wenwei (Rockville, MD), Shen; Min (Boyds, MD), Jiang; Jian-Kang (Columbia, MD)
Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (Washington, DC) THE ROCKEFELLER UNIVERSITY (New York, NY) ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (New York, NY)
Application Number:14/372,488
Patent Claims:see list of patent claims

Details for Patent 9,303,044

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 1978-01-16 ⤷  Free Forever Trial 2032-01-16
Genentech, Inc. ACTIVASE alteplase For Injection 103172 1987-11-13 ⤷  Free Forever Trial 2032-01-16
Genentech, Inc. CATHFLO ACTIVASE alteplase For Injection 103172 2001-09-04 ⤷  Free Forever Trial 2032-01-16
Janssen Biotech, Inc. REOPRO abciximab Injection 103575 1994-12-22 ⤷  Free Forever Trial 2032-01-16
Genentech, Inc. TNKASE tenecteplase For Injection 103909 2000-06-02 ⤷  Free Forever Trial 2032-01-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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