A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
El-Kurdl; Mohammed S. (Pittsburgh, PA), Hong; Yi (Pittsburgh, PA), Soletti; Lorenzo (Pittsburgh, PA), Stankus; John J. (Campbell, CA), Vorp; David A. (Pittsburgh, PA), Wagner; William R. (Pittsburgh, PA)
University of Pittsburgh--Of the Commonwealth System of Higher Education (Pittsburgh, PA)
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