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Last Updated: December 2, 2021

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Patent: 9,217,020

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Summary for Patent: 9,217,020
Title:Constructs for enhancement of gene expression in muscle
Abstract: Efficient and muscle-specific gene expression can be obtained with constructs containing two or more copies of USE and/or .DELTA.USE fused to the minimal promoter of the TnISlow gene. USE is a small (about 160-bp) upstream enhancer of the TnISlow gene that confers slow-twitch muscle fiber specificity. .DELTA.USE is generated from a 100-bp deletion at the 5\' end of USE. .DELTA.USE confers expression in slow- and fast-twitch muscle fibers. The strength and relatively small size (less than 600-bp) of these constructs make them useful for gene therapy applications.
Inventor(s): Blain; Marilyne (Lorraine, CA), Massie; Bernard (Laval, CA), Gilbert; Renald (Montreal, CA)
Assignee: National Research Council of Canada (Ottawa, CA)
Application Number:12/450,939
Patent Claims:see list of patent claims

Details for Patent 9,217,020

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2027-04-17
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2027-04-17
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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