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Last Updated: July 3, 2020

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Patent: 9,205,046

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Summary for Patent: 9,205,046
Title:Enhanced stability of inverse thermal gelling composite hydrogels
Abstract: The present invention relates to a composite hydrogel comprising a blend of an aqueous solution of an anionic polysaccharide or a derivative thereof, such as hyaluronan (also commonly referred to as hyaluronic acid) or a derivative thereof and an aqueous solution of methylcellulose or another water soluble cellulose derivative thereof, having dispersed polymeric particles, such as polymeric hydrophobic particles therein selected from micro particles and nanoparticles, and wherein the stability of the hydrogel is enhanced relative to the stability of the hydrogel alone. The polymeric particles may contain at least one therapeutic agent, in which case each therapeutic agent exhibits a linear sustained release rate that can be tuned or altered by selecting the appropriate polymer formulation of the micro particles and/or nanoparticles. The composite may be injectable, and in the absence of a therapeutic agent may be used as a bulking agent for reconstructive and cosmetic surgery or may act as a platform for subsequent delivery of therapeutic agents.
Inventor(s): Shoichet; Molly S. (Toronto, CA), Baumann; M. Douglas (St. Catharines, CA), Kang; Catherine Elizabeth (Chicago, IL)
Assignee: The Governing Council of the University of Toronto (Toronto, Ontario, CA)
Application Number:12/778,879
Patent Claims:see list of patent claims

Details for Patent 9,205,046

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Ferring Pharmaceuticals Inc. MENOPUR menotropins KIT 021663 1 2004-10-29   Start Trial The Governing Council of the University of Toronto (Toronto, Ontario, CA) 2025-04-25 search
Ferring MENOPUR menotropins (fsh;lh) INJECTABLE;SUBCUTANEOUS 021663 001 2006-03-20   Start Trial The Governing Council of the University of Toronto (Toronto, Ontario, CA) 2025-04-25 RX search
Ferring BRAVELLE urofollitropin INJECTABLE; SUBCUTANEOUS 021484 001 2002-12-19   Start Trial The Governing Council of the University of Toronto (Toronto, Ontario, CA) 2025-04-25 RX search
Ferring BRAVELLE urofollitropin INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS 021289 001 2002-05-06   Start Trial The Governing Council of the University of Toronto (Toronto, Ontario, CA) 2025-04-25 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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McKesson
Colorcon
Baxter
Harvard Business School
Johnson and Johnson
Express Scripts

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