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Last Updated: September 30, 2020

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Patent: 9,193,791

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Summary for Patent: 9,193,791
Title:Development of masked therapeutic antibodies to limit off-target effects
Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
Inventor(s): Williams; John C. (Monrovia, CA), Zer; Cindy (Whittier, CA), Avery; Kendra N. (Pasadena, CA)
Assignee: City of Hope (Duarte, CA)
Application Number:13/424,272
Patent Claims:see list of patent claims

Details for Patent 9,193,791

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial City of Hope (Duarte, CA) 2030-08-03 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial City of Hope (Duarte, CA) 2030-08-03 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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