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Last Updated: September 28, 2020

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Patent: 9,173,885

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Summary for Patent: 9,173,885
Title:Inhibitors
Abstract: The invention relates to novel pyrrolidine derivatives of formula (I): ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
Inventor(s): Heiser; Ulrich (Halle/Saale, DE), Ramsbeck; Daniel (Halle/Saale, DE), Sommer; Robert (Halle/Saale, DE), Meyer; Antje (Halle/Saale, DE), Hoffmann; Torsten (Halle/Saale, DE), Boehme; Livia (Halle/Saale, DE), Demuth; Hans-Ulrich (Halle/Saale, DE)
Assignee: PROBIODRUG AG (Halle/Saale, DE)
Application Number:13/910,702
Patent Claims:see list of patent claims

Details for Patent 9,173,885

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial PROBIODRUG AG (Halle/Saale, DE) 2023-07-16 search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Start Trial PROBIODRUG AG (Halle/Saale, DE) 2023-07-16 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07   Start Trial PROBIODRUG AG (Halle/Saale, DE) 2023-07-16 RX Orphan search
Genzyme LEMTRADA alemtuzumab INJECTABLE;INJECTION 103948 003 2001-05-07   Start Trial PROBIODRUG AG (Halle/Saale, DE) 2023-07-16 RX Orphan search
Biogen Idec TYSABRI natalizumab VIAL; SINGLE-USE 125104 001 2004-11-23   Start Trial PROBIODRUG AG (Halle/Saale, DE) 2023-07-16 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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