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Generated: August 19, 2019

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Patent: 9,169,321

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Summary for Patent: 9,169,321
Title:Activatable binding polypeptides and methods of identification and use thereof
Abstract: Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an \"activatable\" conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Inventor(s): Daugherty; Patrick Sean (Santa Barbara, CA), Stagliano; Nancy (Santa Barbara, CA), Thomas; Jerry (Goleta, CA), Kamath; Kathryn (Santa Barbara, CA), West; James W. (Santa Barbara, CA), Khare; Sanjay (Newbury Park, CA), Sagert; Jason (Santa Barbara, CA)
Assignee: The Regents of the University of California (Oakland, CA) CytomX Therapeutics, Inc. (South San Francisco, CA)
Application Number:13/950,174
Patent Claims:see list of patent claims

Details for Patent 9,169,321

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb YERVOY ipilimumab INJECTABLE; INJECTION 125377 001 2011-03-25   Try a Free Trial The Regents of the University of California (Oakland, CA) CytomX Therapeutics, Inc. (South San Francisco, CA) 2027-08-22 RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,169,321

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2009025846 Feb 26, 2009
World Intellectual Property Organization (WIPO) 2009025846 May 14, 2009
United States of America 10077300 Sep 18, 2018
United States of America 2009304719 Dec 10, 2009
United States of America 2012237512 Sep 20, 2012
United States of America 2012237977 Sep 20, 2012
Country Patent Number Publication Date

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Express Scripts
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