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Last Updated: September 19, 2020

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Patent: 9,164,098

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Summary for Patent: 9,164,098
Title:Determining an expression status of human epidermal growth factor receptor 2 (HER2) in a biological sample
Abstract: A method for determining an expression of human epidermal growth factor receptor 2 (HER2) of a subject. The method includes providing a sample from the subject; measuring one of (i) amounts of two or more proteins in the sample, each protein having a molecular weight substantially equal to 4740, 8404, 8419, 8435, 8450, 8455, 8465, 8570, 8607 or 8626 atomic mass units, and (ii) amounts of at least one of human cystein-rich intestinal protein 1 (CRIP1), one or more variants of the human cystein-rich intestinal protein 1 (CRIP1 variants), and proteolytic digestion products thereof in the sample; and comparing the amounts of the proteins to control amounts, which control amounts are determinative of the expression of the human epidermal growth factor receptor 2.
Inventor(s): Albers; Christian (Bremen, DE), Belau; Eckhard (Lilienthal, DE), Deininger; Soren-Oliver (Leipzig, DE), Rauser; Sandra (Munich, DE), Suckau; Detlev (Grasberg, DE), Walch; Axel (Baldham, DE)
Assignee: Bruker Daltonik GmbH (Bremen, DE)
Application Number:12/879,619
Patent Claims:see list of patent claims

Details for Patent 9,164,098

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Bruker Daltonik GmbH (Bremen, DE) 2029-09-10 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Bruker Daltonik GmbH (Bremen, DE) 2029-09-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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