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Last Updated: November 28, 2021

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Patent: 9,157,084

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Summary for Patent: 9,157,084
Title:Furin-knockdown bi-functional RNA
Abstract: Compositions and methods to attenuate the immunosuppressive activity of TGF-.beta. through the use of bi-functional shRNAs was substituted therefor described herein. The bi-functional shRNAs of the present invention knocks down the expression of furin in cancer cells to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene.
Inventor(s): Nemunaitis; John J. (Cedar Hill, TX), Senzer; Neil (Dallas, TX), Maples; Phillip B. (Pilot Point, TX), Rao; Donald (Dallas, TX)
Assignee: GRADALIS, INC. (Dallas, TX)
Application Number:12/973,787
Patent Claims:see list of patent claims

Details for Patent 9,157,084

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2029-12-23
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2029-12-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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