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Generated: September 16, 2019

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Patent: 9,150,649

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Summary for Patent: 9,150,649
Title:Potent conjugates and hydrophilic linkers
Abstract: Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment. A method for preparing maytansinoids bearing a thioether moiety and a reactive group which allows the maytansinoid to be linked to a cell-binding agent in essentially a single step is also provided.
Inventor(s): Singh; Rajeeva (Framingham, MA), Kovtun; Yelena (Stow, MA), Wilhelm; Sharon D. (Brookline, MA), Chari; Ravi V. J. (Newton, MA)
Assignee: ImmunoGen, Inc. (Waltham, MA)
Application Number:12/574,466
Patent Claims:see list of patent claims

Details for Patent 9,150,649

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Try a Free Trial ImmunoGen, Inc. (Waltham, MA) 2028-04-30 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Try a Free Trial ImmunoGen, Inc. (Waltham, MA) 2028-04-30 RX Orphan search
Genentech PERJETA pertuzumab VIAL; SINGLE-USE 125409 001 2012-06-08   Try a Free Trial ImmunoGen, Inc. (Waltham, MA) 2028-04-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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