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Last Updated: January 24, 2020

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Patent: 9,134,329

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Summary for Patent: 9,134,329
Title:Compositions and methods for drug-sensitization or inhibition of a cancer cell
Abstract: The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The disclosure also provides methods of administering such compositions to cancer cells to sensitize them to drugs, such as chemotherapeutics, or directly inhibit them. The disclosure also provides methods of administering such compositions to increase reactive oxygen species (ROS), particularly superoxides, in cancer cells. The disclosure further provides methods of determining whether a cancer will respond to chemotherapeutics and whether to administer rifamycin or a rifamycin derivative based on ROS levels in cancer cells of a patient.
Inventor(s): Sacchettini; James (College Station, TX), Zhou; Niam (College Station, TX), Baker; Dwight (College Station, TX), Maxwell; Steven A. (College Station, TX), Wallis; Deeann (College Station, TX)
Assignee: The Texas A&M University System (College Station, TX)
Application Number:14/322,727
Patent Claims:see list of patent claims

Details for Patent 9,134,329

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial The Texas A&M University System (College Station, TX) 2032-08-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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