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Last Updated: September 28, 2020

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Patent: 9,133,495

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Summary for Patent: 9,133,495
Title:Hybrid suppressor tRNA for vertebrate cells
Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA\'s, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA\'s/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA\'s (O-tRNA\'s) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
Inventor(s): Tian; Feng (San Diego, CA), Norman; Thea (San Diego, CA), Chu; Stephanie (San Diego, CA)
Assignee: Ambrx, Inc. (La Jolla, CA)
Application Number:12/440,015
Patent Claims:see list of patent claims

Details for Patent 9,133,495

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Lilly HUMULIN R insulin recombinant human INJECTABLE;INJECTION 018780 001 1982-12-02   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 RX search
Lilly HUMULIN R KWIKPEN insulin human SOLUTION;SUBCUTANEOUS 018780 002 1982-12-02   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 RX search
Lilly HUMULIN R insulin human SOLUTION;SUBCUTANEOUS 018780 004 1982-12-02   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 RX search
Lilly HUMULIN R PEN insulin recombinant human INJECTABLE;INJECTION 018780 005 1982-12-02   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 RX search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Ambrx, Inc. (La Jolla, CA) 2026-09-08 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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