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Last Updated: December 1, 2021

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Patent: 9,125,743

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Summary for Patent: 9,125,743
Title:Devitalization and recellularization of cartilage
Abstract: The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps. The present invention is directed to both recellularized cartilage grafts as well as a process for recellularizing cartilage grafts.
Inventor(s): Chen; Silvia Sihui (Derwood, MD), Qin; Xiaofei (Virginia Beach, VA), Chen; Jingsong (Virginia Beach, VA), Wolfinbarger; Lloyd (Norfolk, VA), Moore; Mark (Chesapeake, VA), Thomas; Rony (Virginia Beach, VA), Linthurst Jones; Alyce (Virginia Beach, VA)
Assignee: LifeNet Health (Virginia Beach, VA)
Application Number:11/826,523
Patent Claims:see list of patent claims

Details for Patent 9,125,743

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 2004-05-05 ⤷  Try it Free 2039-02-26
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 2004-12-02 ⤷  Try it Free 2039-02-26
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 2004-10-26 ⤷  Try it Free 2039-02-26
Akorn, Inc. HYDASE hyaluronidase Injection 021716 2005-10-25 ⤷  Try it Free 2039-02-26
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Try it Free 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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