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Last Updated: September 27, 2020

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Patent: 9,115,133

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Summary for Patent: 9,115,133
Title:Substituted fused tricyclic compounds, compositions and medicinal applications thereof
Abstract: The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer\'s disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn\'s disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them. ##STR00001##
Inventor(s): Barawkar; Dinesh (Hinjewadi, IN), Bende; Tanushree (Pune, IN), Zahler; Robert (Pennington, NJ), Bandyopadhyay; Anish (Pune, IN), Sarangthem; Robindro Singh (Pune, IN), Doshi; Jignesh (Pune, IN), Waman; Yogesh (Pune, IN), Jadhav; Rushikesh (Pune, IN), Singh; Umesh Prasad (Pune, IN)
Assignee: Advinus Therapeutics Limited (Bangalore, IN)
Application Number:14/006,630
Patent Claims:see list of patent claims

Details for Patent 9,115,133

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bayer Healthcare Pharms BETASERON interferon beta-1b VIAL; SUBCUTANEOUS 103471 001 1993-07-23   Start Trial Advinus Therapeutics Limited (Bangalore, IN) 2031-03-22 RX Orphan search
Biogen AVONEX interferon beta-1a VIAL 103628 001 1996-05-17   Start Trial Advinus Therapeutics Limited (Bangalore, IN) 2031-03-22 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial Advinus Therapeutics Limited (Bangalore, IN) 2031-03-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Moodys
Medtronic
Mallinckrodt
Johnson and Johnson
Express Scripts
McKesson

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