Patent: 9,114,179

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Summary for Patent: 9,114,179

Title:	Immunoconjugate formulations
Abstract:	The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.
Inventor(s):	Zhang; Wei (Philadelphia, PA), Fleming; Michael S. (Londonderry, NH), Amphlett; Godfrey (Cambridge, MA), Chih; Hung-wei (Burlingame, CA), Bartlett; Elizabeth (Cambridge, MA)
Assignee:	ImmunoGen, Inc. (Waltham, MA)
Application Number:	11/498,139
Patent Claims:	see list of patent claims

Details for Patent 9,114,179

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	RITUXAN	rituximab	VIAL	103705	001	1997-11-26	➤ Sign Up	ImmunoGen, Inc. (Waltham, MA)	2025-08-03	RX		search
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25	➤ Sign Up	ImmunoGen, Inc. (Waltham, MA)	2025-08-03	RX	Orphan	search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 9,114,179

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Country	Patent Number	Publication Date
Australia	2006278573	Feb 15, 2007
Brazil	PI0614100	Mar 09, 2011
Canada	2615122	Feb 15, 2007
>Country	>Patent Number	>Publication Date

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