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Last Updated: September 26, 2020

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Patent: 9,096,840

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Summary for Patent: 9,096,840
Title:Serine protease molecules and therapies
Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
Inventor(s): Rosenblum; Michael G. (Sugar Land, TX), Mohamedali; Khalid Amanali (Houston, TX), Cheung; Lawrence H. (Houston, TX)
Assignee: Research Development Foundation (Carson City, NV)
Application Number:14/046,211
Patent Claims:see list of patent claims

Details for Patent 9,096,840

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Research Development Foundation (Carson City, NV) 2032-10-04 RX Orphan search
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Research Development Foundation (Carson City, NV) 2032-10-04 RX Orphan search
Genentech Inc HERCEPTIN HYLECTA trastuzumab; hyaluronidase-oysk INJECTABLE;SUBCUTANEOUS 761106 001 2019-02-28   Start Trial Research Development Foundation (Carson City, NV) 2032-10-04 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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