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Generated: August 24, 2019

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Patent: 9,095,601

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Summary for Patent: 9,095,601
Title:Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (\"PNAs\") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
Abstract: A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2\'-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
Inventor(s): Becker; Matthew L. (St. Louis, MO), Fang; Huafeng (St. Louis, MO), Li; Xiaoxu (St. Louis, MO), Pan; Dipanjan (St. Louis, MO), Rossin; Raffaella (St. Louis, MO), Sun; Xiankai (St. Louis, MO), Taylor; John Stephen (St. Louis, MO), Turner; Jeffrey L. (St. Louis, MO), Welch; Michael John (St. Louis, MO), Wooley; Karen L. (St. Louis, MO)
Assignee: WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO)
Application Number:13/705,682
Patent Claims:see list of patent claims

Details for Patent 9,095,601

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Amgen NEULASTA pegfilgrastim SYRINGE 125031 001 2002-01-31 ➤ Sign Up WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO) 2024-10-15 RX Orphan search
Spectrum Pharms ZEVALIN ibritumomab tiuxetan INJECTABLE; INJECTION 125019 001 2002-02-19 ➤ Sign Up WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO) 2024-10-15 RX Orphan search
Amgen ARANESP darbepoetin alfa VIAL; SUBCUTANEOUS 103951 010 2001-09-17 ➤ Sign Up WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO) 2024-10-15 RX search
Amgen ARANESP darbepoetin alfa VIAL; SUBCUTANEOUS 103951 009 2001-09-17 ➤ Sign Up WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO) 2024-10-15 RX search
Amgen ARANESP darbepoetin alfa VIAL; SUBCUTANEOUS 103951 008 2001-09-17 ➤ Sign Up WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO) 2024-10-15 RX search
Amgen ARANESP darbepoetin alfa VIAL; SUBCUTANEOUS 103951 007 2001-09-17 ➤ Sign Up WASHINGTON UNIVERSITY IN ST. LOUIS (St. Louis, MO) 2024-10-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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