DrugPatentWatch Database Preview
Patent: 9,073,858
Summary for Patent: 9,073,858
| Title: | Methods of targeted drug development |
| Abstract: | Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR. |
| Inventor(s): | Errico; Joseph P. (Warren, NJ), Mugrage; Benjamin (Cranbury, NJ), Turchi; Ignatius (Yardley, PA), Sills; Matthew (Berkeley Heights, NJ), Ong; Jane (Franklin Park, NJ), Allocco; John (Staten Island, NY), Wines; Pam (Manalapan, NJ) |
| Assignee: | Errico; Joseph P. (Warren, NJ) |
| Application Number: | 14/096,618 |
| Patent Claims: | see list of patent claims |
Details for Patent 9,073,858
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Imclone | ERBITUX | cetuximab | VIAL; INTRAVENOUS | 125084 | 001 | 2004-06-18 | Start Trial | Errico; Joseph P. (Warren, NJ) | 2039-02-26 | RX | Orphan | search |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 9,073,858
| Country | Patent Number | Publication Date |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2011085126 | Feb 23, 2012 |
| World Intellectual Property Organization (WIPO) | 2011085126 | Jul 14, 2011 |
| World Intellectual Property Organization (WIPO) | 2011085129 | Jul 14, 2011 |
| World Intellectual Property Organization (WIPO) | 2011085129 | Sep 01, 2011 |
| World Intellectual Property Organization (WIPO) | 2012012653 | Jan 26, 2012 |
| >Country | >Patent Number | >Publication Date |
