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Last Updated: January 28, 2020

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Patent: 9,073,858

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Summary for Patent: 9,073,858
Title:Methods of targeted drug development
Abstract: Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.
Inventor(s): Errico; Joseph P. (Warren, NJ), Mugrage; Benjamin (Cranbury, NJ), Turchi; Ignatius (Yardley, PA), Sills; Matthew (Berkeley Heights, NJ), Ong; Jane (Franklin Park, NJ), Allocco; John (Staten Island, NY), Wines; Pam (Manalapan, NJ)
Assignee: Errico; Joseph P. (Warren, NJ)
Application Number:14/096,618
Patent Claims:see list of patent claims

Details for Patent 9,073,858

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Imclone ERBITUX cetuximab VIAL; INTRAVENOUS 125084 001 2004-06-18   Start Trial Errico; Joseph P. (Warren, NJ) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 9,073,858

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