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Patent: 9,073,858
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Summary for Patent: 9,073,858
Title: | Methods of targeted drug development |
Abstract: | Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR. |
Inventor(s): | Errico; Joseph P. (Warren, NJ), Mugrage; Benjamin (Cranbury, NJ), Turchi; Ignatius (Yardley, PA), Sills; Matthew (Berkeley Heights, NJ), Ong; Jane (Franklin Park, NJ), Allocco; John (Staten Island, NY), Wines; Pam (Manalapan, NJ) |
Assignee: | Errico; Joseph P. (Warren, NJ) |
Application Number: | 14/096,618 |
Patent Claims: | see list of patent claims |
Details for Patent 9,073,858
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Imclone | ERBITUX | cetuximab | VIAL; INTRAVENOUS | 125084 | 001 | 2004-06-18 | Start Trial | Errico; Joseph P. (Warren, NJ) | 2039-02-26 | RX | Orphan | search |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 9,073,858
Country | Patent Number | Estimated Expiration |
---|---|---|
World Intellectual Property Organization (WIPO) | 2011085126 | Start Trial |
World Intellectual Property Organization (WIPO) | 2011085129 | Start Trial |
World Intellectual Property Organization (WIPO) | 2012012653 | Start Trial |
United States of America | 2011301193 | Start Trial |
>Country | >Patent Number | >Estimated Expiration |