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Last Updated: September 28, 2020

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Patent: 9,005,903

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Summary for Patent: 9,005,903
Title:Immunomodulating compositions and methods of use thereof
Abstract: The invention is directed to .beta.1-6 glucans, compositions, diagnostic kits, and devices comprising the same, and methods of use thereof in modulating immune response and treating, delaying progression of, reducing the incidence or severity of cancer, infection, inflammation, and autoimmune diseases. The .beta.1-6 glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety. The .beta.1-6 glucans of certain embodiments of the invention recruit immunoglobulin G antibodies to mediate complement and neutrophil killing. The conjugated .beta.1-6 glucans of certain embodiments of the invention are targeted to cells to stimulate the immune response at the target location by activating complement-mediated lysis and recruitment of neutrophils.
Inventor(s): Rubin-Bejerano; Ifat (Newton, MA), Fink; Gerald R. (Chestnut Hill, MA)
Assignee: ImmuneXcite, Inc. (Lexington, MA)
Application Number:14/103,015
Patent Claims:see list of patent claims

Details for Patent 9,005,903

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial ImmuneXcite, Inc. (Lexington, MA) 2028-04-29 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial ImmuneXcite, Inc. (Lexington, MA) 2028-04-29 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19   Start Trial ImmuneXcite, Inc. (Lexington, MA) 2028-04-29 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19   Start Trial ImmuneXcite, Inc. (Lexington, MA) 2028-04-29 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial ImmuneXcite, Inc. (Lexington, MA) 2028-04-29 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Start Trial ImmuneXcite, Inc. (Lexington, MA) 2028-04-29 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Harvard Business School
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McKesson

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