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Generated: July 22, 2019

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Patent: 9,005,616

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Summary for Patent: 9,005,616
Title:Methods and compositions for the inhibition of transplant rejection
Abstract: Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation.
Inventor(s): Langermann; Solomon (Baltimore, MD), Liu; Linda (Clarksville, MD)
Assignee: Amplimmune, Inc. (Gaithersburg, MD)
Application Number:13/392,399
Patent Claims:see list of patent claims

Details for Patent 9,005,616

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Bristol Myers Squibb NULOJIX belatacept INJECTABLE; INJECTION 125288 001 2011-06-15 ➤ Try a Free Trial Amplimmune, Inc. (Gaithersburg, MD) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 9,005,616

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Farmers Insurance
Julphar
Merck
Federal Trade Commission
Fish and Richardson
Teva

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