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Last Updated: September 18, 2020

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Patent: 8,999,915

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Summary for Patent: 8,999,915
Title:Methods for attenuating release of inflammatory mediators and peptides useful therein
Abstract: The present invention includes methods of inhibiting or suppressing cellular secretory processes. More specifically the present invention relates to inhibiting or reducing the release of inflammatory mediators from inflammatory cells by inhibiting the mechanism associated with the release of inflammatory mediators from granules in inflammatory cells. In this regard, the present invention discloses an intracellular signaling mechanism that illustrates several novel intracellular targets for pharmacological intervention in disorders involving secretion of inflammatory mediators from vesicles in inflammatory cells. Peptide fragments and variants thereof of MANS peptide as disclosed in the present invention are useful in such methods.
Inventor(s): Parikh; Indu (Chapel Hill, NC)
Assignee: Biomarck Pharmaceuticals, Ltd. (Durham, NC)
Application Number:12/359,892
Patent Claims:see list of patent claims

Details for Patent 8,999,915

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Biomarck Pharmaceuticals, Ltd. (Durham, NC) 2026-07-26 RX search
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial Biomarck Pharmaceuticals, Ltd. (Durham, NC) 2026-07-26 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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